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Suppresses the immune system drug extended the lives of older mice

March 8, 2010

Suppresses the immune system drug extended the lives of older mice
Used to suppress the immune drug sirolimus (brand name – “Rapampitsin) prolongs life in mice by 9 per cent for males and 14 – for females. These results were achieved in the experiments carried out in parallel in the three research centers in the U.S. states of Maine, Michigan and Massachusetts. Article about the study published the journal Nature.

Increased life expectancy was achieved despite the fact that the mouse (there were about two thousand) only started receiving sirolimus at the age of six days, the equivalent of sixty human years. Other known methods of increasing life expectancy of mammals – a healthy lifestyle, physical activity, low-calorie meals – the call for appropriate measures at an early age.

Sirolimus – registered in Russia, a drug used after organ transplantation and to combat certain types of cancer. Not yet determined how effective it would be a means to prolong human life, but that its use can be problematic because of the high toxicity associated with its primary effect. Moreover, the daily dose sirolimusa to humans – from 2 to 5 milligrams – is much lower than that obtained in the mouse experiment (2.24 milligrams per kilogram of body weight per day).

Head of research at the Jackson Laboratory in Bar Harbor (Maine), David Harrison (David Harrison) said: “I would not own and would not recommend anyone to do it [take sirolimus for prolongation of life] at this stage of research.”

The mechanism of increasing the duration while taking the drug remains unclear. Sirolimus was chosen for the experiment because it acts on the biochemical path TOR, which depends on slowing the aging effect of low-calorie diets. Nevertheless, none of the mice did not lose weight during the study.

American scientists have proposed to treat tuberculosis drugs from Parkinson’s disease

American scientists have proposed to treat tuberculosis drugs from Parkinson’s disease
American scientists have discovered that a cure for Parkinson’s disease, entacapone effective in treating “supertuberkuleza, germs which are resistant to most known drugs), reports Newswise. The research skills of the University of California (University of California) in San Diego, published in PLoS Computational Biology.

The researchers used a technique that enables to find a new use of already known medicines. The specialists studied the pharmacological activity of several derivatives of the drug, and then optimize those who showed the greatest efficiency.

Tuberculosis In the study, researchers found that the drug for the treatment of Parkinson’s disease, entacapone is effective against the pathogens of tuberculosis in doses that are well below toxic to human cells. According to study leader, Professor Philip Bourne (Philip Bourne), this discovery is important because existing drugs for the treatment of drug-resistant tuberculosis are highly toxic.

According to scientists, developed the method of investigation will move from the old scheme of search activity of drugs, one drug – one disease “to a new, implying a multiple-use products.