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Long-term receiving ibuprofen and Alzheimer’s disease

November 9, 2008

Long-term receiving ibuprofen and other non-steroid drugs protects against Alzheimer’s disease

That conclusion came from researchers at Boston University in a study involving 250 thousand persons, said the journal Neurology.

Researchers under the leadership of Steven Vlad found that people who took ibuprofen for five years, more than 40% less likely to suffer senile dementia. Other NPVP have less effect – when they receive the risk of senile dementia has fallen on average by 24%, reported the scientists. Some funds from this group, in particular celexocib not have any impact on the development of dementia.

The protective effect of ibuprofen had previously been detected in animal studies, said Vlad. He noted that the admission of the drug led to a reduction of protein deposits in the brain characteristic of Alzheimer’s disease. New data confirm its role in preventing disease.

In previous studies, scientists have analyzed the relationship between the reception NPVP and dementia, but data collected by different authors, have been controversial. Vlad and his colleagues suggested that the discrepancy results linked to the uneven effects of various anti funds and were able to confirm this theory through his research.

Nevertheless, experts still can not recommend that patients use ibuprofen to prevent dementia. NPVP long-term use may cause serious side effects, including breach of kidney function and the formation of gastric ulcer, doctors warn.

Fat cells in the human body

No diet can not change the number of fat cells in the human body, Swedish researchers suggest

Researchers Carolina Institute in Sweden say that the final number of fat cells in humans is formed during adolescence and does not change until the end of life, regardless of the recruited or lost weight.

Increasing the number of people suffering from obesity has led to the focus of scientists – fat cells, the effects of which we notice in our stomach.

When we tolsteem, these cells actually increased in size.

However, according to the journal Nature, scientists could not say for sure whether obesity is only a “broadening” fat cells and also to increase their numbers.

If the latter assumption is confirmed, this would mean that slimming could lead to a reduction in the number of fat cells in the body.

Swedish researchers conducted a study involving several hundred children, adolescents and adults of various ages and found that the number of fat cells grown in childhood, but, having reached a certain number during puberty, remain unchanged.

The researchers also tested the hypothesis that the number of fat cells can be changed in extreme circumstances. To this end, they took samples of fat in patients, in particular, had planned to make a plastic operation to remove fat.

Once people lose weight, researchers took a new piece of fat to see whether the number of fat cells.

It is difficult to lose weight

“This explains why so difficult to lose weight and more it is not to recruit – the very fat cells do not disappear, and require more and more” Kirsti Spadling.
According to lead researcher Kirsti Spadling received data – bad news for wishing to lose weight.
“This explains why so difficult to lose weight and more it is not to recruit – the very fat cells do not disappear, and require more and more” – she said.

Dr. Paul Treyhern from the University of Liverpool believes that the Swedish study is a “solid foundation” for further study of the phenomenon of obesity.

“It would be nice if we could find a way to lose weight by altering the number of fat cells, but there are lots of other, the primary options, such as diet and exercise” – felt Treyhern.

According to him, “the real benefit of [the study] is that it has provided us with evidence that we can use in the future to study obesity and its causes.”

“We know that in many tissues of adult cells, which contain no fat, but may begin to accumulate it, with some modification of diet”
Stephen O’Reilly,
University of Cambridge

However, another scientist, Professor Stephen O’Reilly from Cambridge University said that the idea of a constant number of fat cells in adults do not think it credible.

“We know that in the tissue of adults there are many cells that do not contain fat, but may begin to accumulate it, with some modification of diet,” – says O’Reilly.

“You can almost say with certainty that the cells do so without being divided, and therefore they could not” count “using a similar technique. I think it is premature to conclude that by the time of puberty” game is over “- in meaning the number of fat cells, which we will have. “