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Scientists have explained why the avian flu infected more difficult than usual

October 22, 2009

Scientists have explained why the avian flu infected more difficult than usual
American doctors and biologists have found that the human nose is too cold for the successful spread of avian influenza virus. According to scientists, the bird flu virus infects only cells with a high temperature, whereas the ordinary flu virus is adapted to relatively low temperatures.

Virologists from several different institutions, the U.S. learned the process of infection of cells of the nasal mucosa of different influenza viruses. The researchers varied the temperature: part of the cell culture was maintained at a temperature of 32 degrees, and some – at +37. Biologists know that the bird’s body temperature far above the human and their upper airways are heated as well as the deeply located parts nasopharynx in humans.

Avian influenza viruses (strains that suffer mainly birds: in principle, avian flu can survive in the human body), which scientists infected cells, a well-bred only in the heated cultures. Recall that the virus can not reproduce itself, instead, the virus penetrates the cell, it embeds in its genetic code, and only then the cell starts to produce copies of the virus has infected her.

Researchers have found that often infect humans are influenza viruses, in contrast, well multiply in the cells both at low and at high temperatures. Experts say that these differences are explained by the fact that bird flu infection occurs less frequently, and its transmission from person to person is unlikely: the virus spreads rapidly only when hit deep into the respiratory tract, and under normal circumstances, it is retained in the nasopharynx.

They also said that their discovery could affect the priority of the development of vaccines against avian influenza. Study of the ability of different viruses (currently 16 known strains of avian flu and the doctors have not checked them all) to infect cells at different temperatures can identify those varieties that can infect the body, regardless of the temperature of nasopharynx. Against such a vaccine virus would require first of all – the remaining strains originally adapted to birds with another body temperature.