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The device copes with severe asthma without drugs

November 9, 2009

The device copes with severe asthma without drugs
American scientists tested an experimental device that uses thermal energy to relieve bronchospasm in patients with severe bronchial asthma, intractable medical treatment.

As shown by one of the last stages of clinical trials, the use of Alair System – is the name of the device – a 32% reduced the incidence of severe asthma attacks and 84% of patients reduced the number of requests for emergency medical help.

In addition, patients who were treated by this device rarely took sick and miss school, and days free from asthma symptoms, they were more than those who received placebo.

The test results were presented at the 105-th international conference of the American Thoracic Society, held in San Diego (California, USA) from 15 to 20 May 2009

The principle of the Alair System is as follows: in the respiratory tract is introduced thin tube through which the high-frequency pulses are fed, heating and destroying the excess muscle tissue of the bronchioles, which prevents them from narrowing and obstruction. The procedure called bronchial thermoplastic and an outpatient.

“In bronchial asthma in the wall of the bronchioles, there are too many smooth muscle fibers, which promote the development of seizures, – explains study leader Dr. Mario Castro of the University. George Washington at St. Louis (Missouri, USA). – Our mission – to reduce their numbers” .

To participate in clinical trials, Dr. Castro and his colleagues have invited 297 patients with severe bronchial asthma from 30 hospitals in 6 countries. Two-thirds of all participants received 3 sessions of bronchial thermoplastics, the other represented the control group, in which during the procedure rf pulses were made.

Within a year after the procedure, scientists monitored the condition of patients. In 79% of subjects who passed the experimental treatment, the condition improved. According to Dr. Castro, improvement was noted in the control group, but its severity was not statistically significant. “This is a very important advance in the treatment of bronchial asthma, – said Dr. Castro, – to this day not much we can help these patients.

All patients enrolled in clinical trials, constantly taking a combination of drugs for inhalation of corticosteroids and b-agonists long-acting, but it did not give them much relief. Could also help immunomodulator omalizumab, intended for the treatment of allergic bronchial asthma, but not all patients the cause of asthma in allergy.

This fall, Alair System expects FDA approval. In Europe, bronchial thermoplastic already approved.

Long-term receiving ibuprofen and Alzheimer’s disease

November 9, 2008

Long-term receiving ibuprofen and other non-steroid drugs protects against Alzheimer’s disease

That conclusion came from researchers at Boston University in a study involving 250 thousand persons, said the journal Neurology.

Researchers under the leadership of Steven Vlad found that people who took ibuprofen for five years, more than 40% less likely to suffer senile dementia. Other NPVP have less effect – when they receive the risk of senile dementia has fallen on average by 24%, reported the scientists. Some funds from this group, in particular celexocib not have any impact on the development of dementia.

The protective effect of ibuprofen had previously been detected in animal studies, said Vlad. He noted that the admission of the drug led to a reduction of protein deposits in the brain characteristic of Alzheimer’s disease. New data confirm its role in preventing disease.

In previous studies, scientists have analyzed the relationship between the reception NPVP and dementia, but data collected by different authors, have been controversial. Vlad and his colleagues suggested that the discrepancy results linked to the uneven effects of various anti funds and were able to confirm this theory through his research.

Nevertheless, experts still can not recommend that patients use ibuprofen to prevent dementia. NPVP long-term use may cause serious side effects, including breach of kidney function and the formation of gastric ulcer, doctors warn.