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Role of autoimmune processes in the implantation

November 13, 2009

Role of autoimmune processes in the implantation
In the United States conducted a scientific and experimental work on the process of implantation, when the interaction of the blastocyst with the uterine epithelium. Identified several immune factors that negatively affect the process of implantation.

The study was conducted on a group of women who received the desired pregnancy through IVF treatment. Antiphospholipid antibodies are frequently detected in this group of women, but judging by this study, these antibodies did not affect the number of live births, the frequency of abortion. Antitireodnye antibodies also detected in women of reproductive age, but the frequency rate of successful implantation and pregnancy termination is not changed in women with normal thyroid function. The presence of antinuclear antibodies may be a sign of latent autoimmune zaboevaniya, but the presence of low titer of these antibodies also did not affect the outcome of implantation. Antisperm antibodies, when present, usually occur in women impaired fertility when they are in high titer in the plasma, in the mucous membranes. Antisperm antibodies are often combined with ovarian hypofunction. Thus, in the process of implantation is the interaction of two genetically different immune tissues. In the process of implantation of local and systemic immune factors, cytokines, growth factors may interact with adhesion molecules and other proteins, glycoproteins, peptides.