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American scientists invented insulin cud

September 9, 2009

American scientists invented insulin cud
Researchers at Syracuse University (New York, USA) under the leadership of Robert Doyle  are going to patent the new “dosage form” of insulin – insulin gum, said the magazine New Scientist.

Currently, patients with diabetes receive insulin through injections, which involve a number of inconveniences. That is why scientists around the world are working to create a more patient-friendly dosage form of insulin. Inhalation form of insulin, approved in the United States in 2006, was later withdrawn from sale because of the excessively high cost. And when trying to create a tablet form of drugs, scientists are faced with several challenges: insulin easily destroyed by enzymes of the digestive system and is poorly absorbed into the bloodstream.

Robert Doyle and his colleagues have found an original way to solve the problem. To create a «edible» forms of insulin, they have decided to use a unique mechanism of transport of vitamin B12 in the human body. This vitamin is associated with protein gaptokorrinom, which is secreted by cells of the salivary glands. In such a complex is protected from destruction in the aggressive environment of the stomach. In the small intestine vitamin B12 separated from gaptokorrina and attached to another protein – biermerin that allows vitamin is easily absorbed from the intestine into the bloodstream.

The scientists decided to «attached» insulin molecule to vitamin B12, to use it as a guide. Preliminary tests conducted on rats have shown that this technique actually works.

According to Doyle, the rats received a complex of insulin with vitamin B12 in liquid form, but the people the best way of introducing drugs to use chewing gum. In the process of chewing a large amount of saliva, which contains the necessary drugs for the binding of gaptokorrina, he added.

Insulin, which is in plants, can partly solve the problem of diabetes

September 1, 2008

Researchers from the University of Central Florida found that insulin, which is in plants, can partly solve the problem of diabetes, so far – in laboratory mice.

To date, scientists have created genetically modified tobacco, which is present in leaves more than normal insulin genes. Insulin received thus injected laboratory mice with diabetes for 8 weeks.

Following such a course, scientists determined that levels of blood sugar in normal mice, and their cells produce the required amount of insulin alone.

In the short term, scientists intend to replace tobacco leaf lettuce leaves, because they are less expensive in production, but also in their cases could be avoided stigmatsii (damaged skin), tobacco-related.

U.S. National Institute of Health has already allocated for this study, 2 million dollars. The date of commencement of testing on humans at the university has not yet been reported.