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Scientists have found that Alzheimer’s disease is directly linked to heart problems

October 22, 2009

Scientists have found that Alzheimer’s disease is directly linked to heart problems
According to recent research scientists, people with atrial fibrillation in 44% more prone to dementia than people with healthy hearts. Atrial fibrillation – one of the most common cardiac arrhythmia. It is characterized by chaotic atrial rhythm and occurs in all age groups.

Academic Medical Center The Intermountain Medical Centre in Utah (USA) monitored the condition of more than 37 thousand patients. According to the cardiologist Jared Bunch, previous studies have shown that patients with atrial fibrillation are predisposed to vascular dementia – a kind of dementia, the prevalence is second only to Alzheimer’s disease. In the new study was the discovery is the fact that heart disease and lead to the development of Alzheimer’s disease.

Dr. Susan Sorensen, head of the U.S. Alzheimer’s Society, said: “The discovery suggests that people with heart disease may be faced immediately with the two most serious forms of dementia – Alzheimer’s disease and vascular dementia. However, we have the opportunity to thoroughly explore this phenomenon and, possibly, to find the right medicine. ”

For 2006, there were more than 26 million people suffering from Alzheimer’s disease. Scientists project that by 2050 their number may increase by several times.

Further study of this problem should show whether you can find a connection between the treatment of heart disease and reduced incidence of dementia, reports The Daily Telegraph.

Statins reduce the risk of first or recurrent stroke

October 19, 2009

Statins reduce the risk of first or recurrent stroke
Results of large-scale meta-analysis indicate that the use of statins reduces the risk of both first and recurrent stroke.

Pierre Amarenco, and Julien Labreuche (Hemostasis, Bio-engineering, and Cardiovascular Remodeling Unit at INSERM in Paris, France) performed a meta-analysis study of stainov, it included 24 studies with a total of 165 792 participants.

In a meta-analysis showed that lowering LDL cholesterol by 1 mmol / L reduces the risk of stroke by 21.1%. Only one study examined the effectiveness of statins for secondary prevention of stroke, found that patients who took statins, the risk of recurrent stroke was 0.84.

Lancet Neurol 2009

The aging of the brain responsible sugar

September 9, 2009

The aging of the brain responsible sugar
Increased blood sugar levels, a normal sign of aging, affects the work of the hippocampus – the area of the brain, which is crucial for learning and memory. Scientists believe that it is too high blood glucose levels associated with cognitive dysfunction in old age.

It is assumed that the regulation of substances in the body will help prevent age-related decline in memory. At the same time, neurologists noticed that the excercises stabilize the concentration of glucose and, consequently, improve brain function.

Research at Columbia University / United States / showed that physical activity strengthens the part of the brain associated with aging by controlling blood sugar. Such conclusions were made after analysis of the functions of the hippocampus in 240 healthy people about 80 years. It is known that damage to the hippocampus develops Alzheimer’s disease and other cognitive problems. Doctors argue that maintaining optimal blood sugar levels and the implementation of regular physical exercise can effectively prevent a cognitive disorder and to support brain activity in old age.

American scientists invented insulin cud

American scientists invented insulin cud
Researchers at Syracuse University (New York, USA) under the leadership of Robert Doyle  are going to patent the new “dosage form” of insulin – insulin gum, said the magazine New Scientist.

Currently, patients with diabetes receive insulin through injections, which involve a number of inconveniences. That is why scientists around the world are working to create a more patient-friendly dosage form of insulin. Inhalation form of insulin, approved in the United States in 2006, was later withdrawn from sale because of the excessively high cost. And when trying to create a tablet form of drugs, scientists are faced with several challenges: insulin easily destroyed by enzymes of the digestive system and is poorly absorbed into the bloodstream.

Robert Doyle and his colleagues have found an original way to solve the problem. To create a «edible» forms of insulin, they have decided to use a unique mechanism of transport of vitamin B12 in the human body. This vitamin is associated with protein gaptokorrinom, which is secreted by cells of the salivary glands. In such a complex is protected from destruction in the aggressive environment of the stomach. In the small intestine vitamin B12 separated from gaptokorrina and attached to another protein – biermerin that allows vitamin is easily absorbed from the intestine into the bloodstream.

The scientists decided to «attached» insulin molecule to vitamin B12, to use it as a guide. Preliminary tests conducted on rats have shown that this technique actually works.

According to Doyle, the rats received a complex of insulin with vitamin B12 in liquid form, but the people the best way of introducing drugs to use chewing gum. In the process of chewing a large amount of saliva, which contains the necessary drugs for the binding of gaptokorrina, he added.