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Found a cure for skin cancer

November 13, 2009

Found a cure for skin cancer
Scientists have developed a new drug that helps in the treatment of the most deadly types of skin cancer, including the most recent stages.

Malignant melanoma – one of the fastest growing types of cancer. Main reason for it – the solar radiation. According to the results of preliminary tests, the drug while still under development and which bears the name of PLX4032 (R7204), can provide a long life expectancy.

Pharmaceutical companies Roche and Plexxikon announced the results of their research at the annual convention of the American Society of Clinical Oncology. PLX4032 (R7204) finds and destroys tumor cells carry the mutation type BRAF, which is present in 60% of malignant melanomas. This can help not only reduce the number of malignant tumors, but also slow the spread of cancer.

Clinical trials

Currently, only 5% of people live more than two years after the appearance of metastases. In the first phase of a clinical study in 16 patients receiving the drug PLX4032 (R7204) was found to decrease proliferation of tumor cells by at least 30%.

On average, these patients have stopped the cancer cells to spread about half a year, while more than half of the tumors were markedly reduced. Representatives of the companies Roche and Plexxikon reported that they are going to conduct a more extensive clinical trials to determine how toxic the drug may be and what should be its optimal dose.

Both companies also hope to develop a process of testing for the diagnosis of patients with melanoma-type BRAF in the early stages of its development.

Against a stomach ulcer will help the amino acid glutamine

November 9, 2009

Against a stomach ulcer will help the amino acid glutamine
Almost 20 years ago, it was found that the bacteria called Helicobacter Pylori is responsible for stomach ulcers. Since then, antibiotics have become the main way to combat bacterial infection that affects approximately six percent of the world’s population, as well as the main cause of stomach cancer.

But today, the bacteria become increasingly resistant to antibiotics. American researchers Medical Center Beth Israel Deaconess and the Massachusetts Institute of Technology have found an alternate method of prophylaxis against gastric ulcers: they believe that the amino acid glutamine to be helpful against damage to the stomach bacteria. According to gastroenterologists, glutamine supplement in the diet will protect the stomach from the effect of H. PYLORI, which weakens the mucous membranes and affects the work of cells, causing an excessive immune response is ineffective against the infection. Glutamic supplements will prevent the development of gastritis and conditions that lead to cancer, doctors believe.

Glutamine is found in many foods, including beef, chicken, fish, eggs, dairy products and some fruits and vegetables. Experiments have shown that glutamate blocks bacterial cell death, completely reversing the process of gastric lesions in the production of ammonia by bacteria. Amino acid stimulates the detoxification of ammonia in the stomach, reducing its concentration and prohibiting cell damage, demonstrated by clinicians who have observed the action of glutamine in the body of laboratory mice for 20 weeks. With supplements substance in the animals there was a decrease of inflammation and activity of inflammatory cytokines.